Mucin Dynamics in Intestinal Bacterial Infection

Mucin Dynamics in Intestinal Bacterial Infection

BACKGROUND Bacterial gastroenteritis causes morbidity and mortality in humans worldwide. Murine Citrobacter rodentium infection is a model for gastroenteritis caused by the human pathogens enteropathogenic Escherichia coli and enterohaemorrhagic E. coli. Mucin glycoproteins are the main component of the first barrier that bacteria encounter in the intestinal tract. METHODOLOGY/PRINCIPAL FINDI...

Intestinal Pathogenic Bacterial Infection

Synergy between bacterial infection and genetic predisposition in intestinal dysplasia.

Accumulating evidence suggests that hyperproliferating intestinal stem cells (SCs) and progenitors drive cancer initiation, maintenance, and metastasis. In addition, chronic inflammation and infection have been increasingly recognized for their roles in cancer. Nevertheless, the mechanisms by which bacterial infections can initiate SC-mediated tumorigenesis remain elusive. Using a Drosophila mo...

The intestinal flora and bacterial infection in cirrhosis.

Bacterial infection, especially with intestinal-type bacterial flora, is a common complication in patients with cirrhosis [1–4]. Spontaneous bacterial peritonitis (SBP), urinary tract infection, pneumonia, spontaneous bacterial empyema and bacteraemia are the most frequent infective complications in this group. The incidence of infection with Gram-positive cocci, in particular, has increased in...

Vasoactive intestinal peptide upregulates MUC2 intestinal mucin via CREB/ATF1.

VIP exerts a spectrum of effects as a potent anti-inflammatory factor. In addition, VIP increases expression of MUC2, a major intestinal secretory mucin. We therefore investigated the effects of VIP on the promoter activity of the 5'-flanking region of the MUC2 gene. VIP activated MUC2 transcription in human colonic epithelial cells via cAMP signaling to ERK and p38. cAMP/Epac/Rap1/B-Raf signal...